Prognostic Values of Albumin and Iron in Symptomatic HIV/Malaria Co-infected subjects on ART in Nnewi, South Eastern Nigeria

  • NR Ukibe
  • CC Onyenekwe
  • JE Ahaneku
  • SN Ukibe
  • A Ilika
  • M Ifeanyi
  • AO Igwegbe
  • M Ezeani
  • N Ofiaeli

Abstract

This study was designed to assess the prognostic value of albumin and iron in symptomatic HIV subjects on ART with or without malaria infection. 150 participants (male, n=65, female, n=85) aged between 17 and 70 years were recruited for the study at the HIV clinic of Nnamdi Azikiwe University Teaching Hospital Nnewi, Nigeria and grouped as Symptomatic HIV subjects (n=68) of which 33 had malaria co-infection; Symptomatic HIV subjects on ART (n=47) of which 28 had malaria infection; and HIV seronegative subjects (n=40) of which 20 had malaria infection. HIV and Plasmodium falciparum antigen screening, CD4+ count, packed cell volume, serum albumin and iron were determined using standard laboratory methods. The results showed that positive associations were observed between CD4+ count and PCV (r=0.347, P<0.05) in symptomatic HIV subjects on ART with or without malaria and between CD4 count and serum iron (r=0.487, P<0.05). Positive associations were also observed between CD4+ count and serum albumin (r=0.301, P<0.01) in the same group of subjects. The implication of these relationships is that as HIV/AIDS progressed, the CD4+ T cells become more depleted and biochemical parameters like serum albumin and iron become reduced due to reduced intake and reduced hepatic synthesis. The prognostic implication of this observation was discussed.

Keywords: Albumin, iron deficiency, HIV, malaria, serum albumin

Nigerian Journal of Parasitology, Vol. 32 [1] March 2011, pp.11-17

Author Biographies

NR Ukibe
Department of Human Biochemistry, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, P.M.B. 5001 Nnewi, Anambra State, Nigeria
CC Onyenekwe
Deparment of Medical Laboratory Science, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, P.M.B. 5001 Nnewi, Anambra State, Nigeria
JE Ahaneku
Department of Chemical Pathology, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, P.M.B. 5001 Nnewi, Anambra State, Nigeria
SN Ukibe
Department of Prosthesis and Orthopedic Technology, School of Health Technology, Federal University of Technology, P.M.B. 1526 Owerri
A Ilika
Department of Community Medicine, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, P.M.B. 5001 Nnewi, Anambra State, Nigeria
M Ifeanyi
Department of Immunology, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, P.M.B. 5001 Nnewi, Anambra State, Nigeria
AO Igwegbe
Department of Obstetric and Gynecology, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, P.M.B. 5001 Nnewi, Anambra State, Nigeria
M Ezeani
Department of Immunology, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, P.M.B. 5001 Nnewi, Anambra State, Nigeria
N Ofiaeli
HVCT Unit, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria
Published
2013-12-29
Section
Articles

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