Effect of Aqueous Fruit Extract of Xylopia Aethiopica on Intestinal Fluid and Glucose Transfer in Rats

  • OO Okwari
  • RO Nneli
  • EE Osim


Intestinal fluid and glucose absorption was studied in jejunal and ileal segments in Xylopia aethiopica fed rats using inverted sac technique. Thirty male Wistar rats were assigned into three groups of 10 rats each; control, 100mg/kg and 200mg/kg Xylopia aethiopica treated groups. The control group received normal rat chow and water while the low dose and high dose groups received oral administration of Xylopia aethiopica extract at doses of 100mg/kg and 200mg/kg body weight respectively in addition to daily rat chow and water intake for 28 days. The results showed significant reduction and increase in fluid transfer in the jejunum and ileum respectively (P<0.01) compared with control. 100mg/kg increased gut fluid uptake in the ileum while 200mg/kg treatment reduced uptake in jejunum compared with control. Both doses had significantly increased jejunal and ileal glucose transfer. Gut glucose uptake was increased in jejunum and ileum of Xylopia aethiopica treated groups. Both doses increased the crypt depth but significantly decreased the villus height in the ileum (P<0.05). In conclusion, increased ileal gut fluid uptake may be beneficial in diarrheal state while an enhanced glucose uptake implies that glucose substrate may be made available to cells for synthesize of ATP for cellular activities.

Keywords: Xylopia aethiopica, Glucose, Absorption, Jejunum, Ileum, Rat

Nig. J. Physiol. Sci. 25(December 2010) 181 – 186

Author Biographies

OO Okwari
Department of Physiology, College of Medical Sciences, University of Calabar, Calabar, Nigeria
RO Nneli
Department of Physiology, College of Health Sciences, Abia State University, Uturu, Nigeria
EE Osim
Department of Physiology, College of Medical Sciences, University of Calabar, Calabar, Nigeria

Journal Identifiers

eISSN: 0794-859X