Efficiency of sirolimus in prevention of adhesions around vascular grafts

Abstract

Background: Adhesions due to the reactions caused by the grafts used in the primary vascular operation can lead to various problems when a secondary operation is necessary. These problems include: bleeding, injuries to neighboring organs sand complications occurring due to a prolonged operation. We investigated the affects of sirolimus, which has antiproliferative effects on vascular adhesions.

Methods: The abdominal aortae of rats were explored and abrasions inflicted. Following the fixation of a PTFE (Polytetra floroetilen) graft on the abdominal aorta, rapamycin (sirolimus) was applied (in powder form) on the grafts of the study group. Four weeks later a laparotomy was done and the adhesions developed were evaluated.

Results: In the study group the adhesions were determined to be fewer in number and milder in severity. Severe adhesion were noted in the control group.

Conclusions: Therefore, sirolimus applied around the prosthesis in vascular operations, was determined to be effective in preventing possible adhesions.

Keywords: Sirolimus (Rapamycin), adhesion

Nigerian Journal of Surgical Research Vol. 7(3&4) 2005: 285-289