Sarcomatous Change in Polyostotic Paget's Disease-A Diagnostic Conundrum

  • H.C. Nwadiaro Department of Surgery, Jos University Teaching Hospital, Jos
  • A.N. Manasseh Department of Histopathology, Jos University Teaching Hospital, Jos
  • A.Z. Mohammed Department of Histopathology, Jos University Teaching Hospital, Jos
Keywords: Paget's disease, Sarcomatous change


This is a report of a 56-year-old man presented to highlight the clinical features and diagnostic difficulties of Paget's disease in our environment. The patient had a four year history of intractable body pains and at different times had pathological fracture, loss of vision, conductive hearing loss, frequent intermittent anaemia requiring blood transfusion, paraparesis, one sided headache, cardiac failure and suspected Foster Kennedy syndrome. An earlier bilateral orchidectomy was done for suspected metastatic carcinoma of the prostate following markedly elevated acid phosphatase and ESR in the presence of enlarged hard prostate but a trucut biopsy of the gland later showed no evidence of malignancy. A multidisciplinary clinical assessment along with sequential ancillary test, roentgenography and bone marrow study helped to arrive at the eventual diagnosis

(Nig J Surg Res 2000; 2:88-91)


Paget's disease, Sarcomatous change

Journal Identifiers

eISSN: 1595-1103