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Development of metamaterial-based biosensor for biomedical applications
Abstract
Breast cancer is one of the most commonly diagnosed cancers among women. For fast and effective treatment of breast cancer, early detection is inevitable. Material characterization or detection is essential for identifying the specific type of material suited for a given application, whether it is a solid, semi-solid, liquid, or powdered sample. This study presents a biosensor that utilizes metamaterials to detect cancerous cells through their electrical properties for clinical diagnostics. The design features a rectangular patch microstrip-fed grounded planar structure with a split ring resonator (SRR) loaded at two ports. The SRR is constructed utilizing its inductive and capacitive resonance characteristics, rendering it an appropriate sensing option. Using the four different breast cancer cells as material detection units and air as a reference, detection is performed. The evaluation of the sensor's performance involves the analysis of four distinct breast cancer cells: HS578, MCF-7, MDA-MB-231, and MDA-2. The RLC equivalent circuit has been introduced to enhance the comprehension of the sensor's functionality. The measurement outcomes of the prototype sensor aligned closely with simulated results derived from the computer simulation technology suite (CST) and Advanced design system (ADS). The biosensor can be suitably integrated into clinical diagnostic tools for the early detection and classification of breast cancer. This will potentially enable timely detection of cancer and precise treatment of breast cancer.


