Is there any relationship between Chlamydophila pneumoniae and coronary atherosclerosis among Iranians?

  • Mohammad Hadi Sadeghian
  • Seyed Abbas Tabatabaee Yazdi
  • Hossein Ayatollahi
  • Mohammad Reza Keramati
  • Kiarash Ghazvini
  • Ali Reza Rezai
  • Nasrin Heidari
  • Maryam Sheikhi
  • Gohar Shaghayegh

Abstract

Background: Atherosclerosis is a coronary heart disease, andis the most common cause of death in the industrialized world. Some studies suggested that atherosclerosis may be triggered by infectious agents, mostly Chlamydophila pneumoniae. However, the role of C. pneumoniae in the pathogenesis of coronary atherosclerosis is still controversial. Objectives: This study was performed to evaluate whether there is a significant association between coronary artery atherosclerosis and C. pneumoniae by the polymerase chain reaction (PCR) method. Materials and Methods: This case‑control study was carried out on formalin‑fixed paraffin‑embedded tissue biopsies of the coronary arteries obtained from 30 patients with coronary atherosclerosis and 30 subjects without atherosclerosis living in Northeast of Iran. All subjects’ weight and height were determined, and the body mass index was calculated. We also reviewed the medical history and previous laboratory reports of patients. Deoxyribonucleic acid (DNA) was extracted, and C. pneumonia DNA was amplified and detected using PCR assay. Results: The age of the patients in the study group was from 18 to 50 years, and the male to female ratio was 5:1. Only oneout of the 30 coronary tissue samples had positive PCR for C. pneumoniae (3.3%), while it was negative for patients in the control group. Conclusions: This study showed that C. pneumoniae infection is not strongly associated with coronary artery atherosclerosis in Northeast of Iran.

Keywords: Atherosclerosis, Chlamydophila pneumonia, coronary artery, Iran

Nigerian Medical Journal | Vol. 54 | Issue 1 | January-February | 2013

Author Biographies

Mohammad Hadi Sadeghian
Faculty of Medicine, Cancer Molecular Pathology Research Centre, Ghaem Medical Centre
Seyed Abbas Tabatabaee Yazdi
Department of Pathology, Ghaem Medical Centre
Hossein Ayatollahi
Faculty of Medicine, Cancer Molecular Pathology Research Centre, Ghaem Medical Centre
Mohammad Reza Keramati
Neonatal Research Centre, Faculty of Medicine, Imam Reza Medical Centre
Kiarash Ghazvini
Department of Microbiology, Ghaem Medical Centre
Ali Reza Rezai
Department of Hematology and Blood Bank, Ghaem Medical Centre
Nasrin Heidari
Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Maryam Sheikhi
Faculty of Medicine, Cancer Molecular Pathology Research Centre, Ghaem Medical Centre
Gohar Shaghayegh
Faculty of Medicine, Cancer Molecular Pathology Research Centre, Ghaem Medical Centre
Published
2014-07-14
Section
Articles

Journal Identifiers


eISSN: 2229-774X
print ISSN: 0300-1652