Hyper-reactive Malarial Splenomegaly: A Case Report and Review of the Management and Pathogenesis.

Abstract

Hyper-reactive malarial splenomegaly is thought to represent a dysfunctional immune response to recurrent malaria infection. A 14 year old male child with hms, hypersplenism, ascites and peripheral lymphadenopathy is reported. There was initial poor response to proguanil aggravated by non compliance. He was started on a combination of proguanil and chloroquine with
counseling and showed good and fast response. A review of the management and recent concept of pathogenesis is presented.

Niger Med J. Vol. 50, No. 4, Oct.–Dec., 2009:97–99

Key words: Hyper-reactive malarial splenomegaly,
management, pathogenesis