Molecular Mechanisms for the Potential Therapeutic Effects of FDY003 in the Treatment of Cervical Cancer, Utilizing a Network Pharmacology Approach

Abstract

Cervical cancer remains a prominent global health issue, requiring novel strategies to comprehend its molecular underpinnings and devise efficacious therapeutic interventions. This research utilizes network pharmacology to investigate the intricate interactions of molecular components involved in cervical cancer therapy. The study recognizes the difficulties connected with fully addressing the complex nature of this illness. The study proposed a novel approach to treating Cervical Cancer to address the issues using the Network Pharmacology Approach (TCC-NPA). The proposed system incorporates many components, such as functional enrichment analysis, molecular docking, and survival analysis, to elucidate complex pathways and critical molecular interactions. This study reveals hub nodes, including TP53, SRC, AKT1, and other relevant factors, providing insights into their functions in cervical cancer. The research findings indicate that elevated TP53, ESR1, and AKR1C3 levels and reduced AKT1, VEGFA, JUN, and EGFR correlate with enhanced survival outcomes among individuals diagnosed with cervical cancer. Quercetin and luteolin play a significant role in the therapeutic effects exhibited by FDY003. The results highlight the potential of FDY003 and TCC-NPA as a holistic strategy for treating cervical cancer. This research explores the possibility of targeting various pathways and biological processes, presenting novel opportunities for developing more efficient and individualized therapy approaches.