Chlorpyrifos chronic toxicity in broilers and effect of vitamin C

  • AM Kammon
  • RS Brar
  • S Sodhi
  • HS Banga
  • J Singh
  • NS Nagra
Keywords: chlorpyrifos, chronic toxicity, clinicopathology, vitamin C, broilers

Abstract

An experiment was conducted to study chlorpyrifos chronic toxicity in broilers and the protective effect of vitamin C. Oral administration of 0.8 mg/kg body weight (bw) (1/50 LD50) chlorpyrifos (Radar®), produced mild diarrhea and gross lesions comprised of paleness, flaccid consistency and slightly enlargement of liver. Histopathologically, chlorpyrifos produced degenerative changes in various organs. Oral administration of 100 mg/kg bw vitamin C partially ameliorated the degenerative changes in kidney and heart. There was insignificant alteration in biochemical and haematological profiles. It is concluded that supplementation of vitamin C reduced the severity of lesions induced by chronic chlorpyrifos toxicity in broilers.

Keywords: chlorpyrifos, chronic toxicity, clinicopathology, vitamin C, broilers

Published
2011-02-25
Section
Articles

Journal Identifiers


eISSN: 2218-6050
print ISSN: 2226-4485