PROMOTING ACCESS TO AFRICAN RESEARCH

Open Veterinary Journal

Log in or Register to get access to full text downloads.

Remember me or Register



Calcitonin-negative primary neuroendocrine tumor of the thyroid (nonmedullary) in a dog

E.A. Soler Arias, V.A. Castillo, M.E. Caneda Aristarain

Abstract


The Calcitonin-negative neuroendocrine tumor of the thyroid (CNNET) or "nonmedullary" in humans is a rare tumor that arises primarily in the thyroid gland and may be mistaken for medullary thyroid carcinoma; it is characterized by the immunohistochemical (IHC) expression of neuroendocrine markers and the absence of expression for calcitonin. An Argentine dogo bitch showed a solid, compact thyroid tumor, which was IHC negative for the expression of calcitonin, carcinoembryonic antigen, thyroglobulin and S100 protein, and positive for synaptophysin and cytokeratin AE1-AE3. The Ki-67 proliferation index was low. We cite this case not only because it is the first case report of calcitonin-negative primary neuroendocrine tumor of the thyroid in dogs but also because we want to highlight the diagnostic importance of IHC in this regard.

Keywords: Calcitonin-negative, Immunohistochemistry, Ki-67, Medullary thyroid carcinoma, Neuroendocrine




http://dx.doi.org/10.4314/ovj.v6i3.10
AJOL African Journals Online