Schizophrenia and Leigh syndrome, a simple comorbidity or the same etiopathogeny: about a case
AbstractLeigh syndrome is a mitochondrial encephalomyopathy that occurs due to "cytochrome c oxidase deficiency". Few psychiatric disorders have been defined that are associated with Leigh syndrome. The objective of this work is to study relations between mitochondrial dysfunction and psychiatric disorders. It was a 20 year old male patient, who received Modopar, for severe extra pyramidal symptoms caused by Leigh syndrome. He developed, four months ago, acute psychotic symptoms such as audio-visual hallucinations, persecution and mystic delirium. The cerebral MRI has shown signal abnormalities in central grey nucleus. The EEG recording and blood test were normal. The hypothesis of drug induced psychiatric disorders (Modopar) was possible. The evolution under atypical antipsychotic was only partial. In this case, the cerebrospinal fluid and lactate levels mean that mitochondria were not an overall explanation for these psychiatric disorders but may at least play a partial role. Psychiatric disorders may just be acomorbidity.
Pan African Medical Journal 2015; 22
Brief summary of the agreement Anyone is free: · to copy, distribute, and display the work; · to make derivative works; · to make commercial use of the work; Under the following conditions: Attribution · the original author must be given credit; · for any reuse or distribution, it must be made clear to others what the license terms of this work are; · any of these conditions can be waived if the authors gives permission. Statutory fair use and other rights are in no way affected by the above