Epidemiological and clinical characteristics of malignant melanoma in Southeast Anatolia in Turkey

  • Bilal Sula
  • Feyzullah Uçmak
  • Mehmet Ali Kaplan
  • Zuhat Urakçi
  • Mustafa Arica
  • Abdurrahman Isikdogan

Abstract

Introduction: The present study aimed to establish the epidemiological and clinical characteristics of patients who were histopathologically diagnosed with malignant melanoma (MM). Methods: The present study retrospectively analyzed the data of 78 patients who were histopathologically diagnosed with MM in Dicle University Medical Faculty, Dermatology and Medical Oncology departments between 2005 and 2014. Results: The study included 78 patients in total with 44 (56.4%) male and 34 (43.6%) female. Median age of the patients was 62.50 years (range: 27 - 84 years). Of the patients, 78.2% (n=61) had cutaneous melanoma, 8.9% had solid organ melanoma, and 2.5% had ocular and mucosal melanoma. The most common tumor localization among the patients was the lower extremities with 29.4% (n=23). The most common histopathological type was nodular malignant melanoma with 35.8% (n=28). Based on TNM, Clark and Breslow classifications, 26.9% (n=21) of the patients were stage 4, 26.9% (n=21) were Clark stage 4, and 37.1% (n=29) were Breslow stage 4. Median overall survival in all patients was 14.9 months (95% CI 10.9 - 18.8 months). In the multivariate Cox analysis, only stage statistically significantly affecting survival [odds ratio (OR): 0.54; (95% CI 0.16-1.82, p=0.02)]. Conclusion: Malignant melanoma data are also important for the optimal utilization of effective methods and healthcare resources to prevent the disease. In order to minimize MM mortality and morbidity, not only the society but also physicians from primary and secondary care hospitals should become familiar with melanoma.

Pan African Medical Journal 2016; 24

Author Biographies

Bilal Sula
Department of Dermatology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey
Feyzullah Uçmak
Department of Gastroenterology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey
Mehmet Ali Kaplan
Department of Medical Oncology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey
Zuhat Urakçi
Department of Medical Oncology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey
Mustafa Arica
Department of Dermatology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey
Abdurrahman Isikdogan
Department of Medical Oncology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey
Published
2016-08-29
Section
Articles

Journal Identifiers


eISSN: 1937-8688