Pan African Medical Journal

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Prolonged neuromuscular block in a preeclamptic patient induced by magnesium sulfate

Mohamed Adnane Berdai, Smael Labib, Mustapha Harandou


Recent large use of magnesium in the obstetric population should incite anesthesiologists to control its side effects and drugs interactions. We report a case of a 30-year-old woman, with severe preeclampsia and HELLP syndrome, receiving sulfate magnesium and nicardipine, who underwent a cesarean section under general anesthesia. She developed a prolonged and deep neuromuscular blockade, which was antagonized three hours later with neostigmine. In case of therapeutic hypermagnesaemia, non-depolarizing relaxants must be used in reduced doses, and at increased time intervals, with appropriate neuromuscular monitoring.

The Pan African Medical Journal 2016;25