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Syndrome de résistance à l’Adrénocorticotrophine Hormone (ACTH): à propos d’un cas


Morgiane Solange Tognidé Sêlomin Houngbadji
Babacar Niang
Djibril Boiro
Aminata Mbaye
Abdoulaye Seck
Abdoulaye Aliou Ndongo
Indou Deme Ly
Ousmane Ndiaye

Abstract

Adrenocorticotropic hormone (ACTH) insensitivity syndrome is one of the rare causes of adrenal insufficiency in children. All described inherited ACTH insensitivity forms are of autosomal recessive origin. In our resource-poor Countries, many of these rare diseases are ignored or not diagnosed due to inadequate technical equipments. We report the case of a 4-month old infant hospitalized for refractory hypoglycaemias. Despite the patient had generalized and severe melanodermia, digestive disorders and ion channel disorders the diagnosis of cortisol deficiency was only diagnosed retrospectively during respiratory arrest with favorable outcome under hydrocortisone therapy. This study aims to highlight the clinical, laboratory and therapeutic features of peripheral cortisol deficiency, without enzymatic blocks, including this adrenocorticotropic hormone (ACTH) insensitivity syndrome.

Keywords: ACTH resistance, cortisol deficiency, hypoglycaemia

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eISSN: 1937-8688