On artherogenic index of plasma in sickle cell anaemia patients

  • Akinsegun Abduljaleel Akinbami Department of Haematology and Blood Transfusion, Lagos State University, College of Medicine PMB 21266, Ikeja, Lagos, Lagos State, Nigeria
  • Ebele Ifeyinwa Uche Department of Haematology and Blood Transfusion, Lagos State University, College of Medicine PMB 21266, Ikeja, Lagos, Lagos State, Nigeria
  • Aishatu Maude Suleiman Department of Haematology and Blood Transfusion, Faculty of Basic Clinical Sciences, College of Health Sciences, Ahmadu Bello University, Zaria, Nigeria
  • Ann Abiola Ogbena Department of Haematology and Blood Transfusion, Faculty of Clinical Sciences, College of Medicine, University of Lagos, Nigeria
  • Festus Olusola Olowoselu Department of Haematology and Blood Transfusion, Faculty of Clinical Sciences, College of Medicine, University of Lagos, Nigeria
  • Benjamin Augustine Department of Haematology and Blood Transfusion, Faculty of Basic Clinical Sciences, College of Health Sciences, Ahmadu Bello University, Zaria, Nigeria
  • Mulikat Adesola Badiru Department of Hematology and Blood Transfusion, Lagos State University, Teaching Hospital, PMB 21266, Ikeja, Lagos State, Nigeria
  • Rafat Abiodun Bamiro Department of Hematology and Blood Transfusion, Lagos State University, Teaching Hospital, PMB 21266, Ikeja, Lagos State, Nigeria
  • Omolara Risqat Kamson Department of Hematology and Blood Transfusion, Lagos State University, Teaching Hospital, PMB 21266, Ikeja, Lagos State, Nigeria
Keywords: Artherogenic index of plasma; lipid profile; sickle cell disease

Abstract

Introduction: Sickle cell anaemia (SCA) is an inherited abnormality of haemoglobin associated with reduced life expectancy. Patients' complications include dyslipideamia. This study was aimed at determining the artherogenic index of plasma (AIP) in sickle cell anaemia patients and compares the value to HbAA controls value. A high AIP is strongly predictive of elevated cardiovascular risk.

Methods: a comparative study was conducted among SCA patients attending the haematology clinic, Lagos State University Teaching Hospital (LASUTH) and HbAA Phenotype controls. A total of 304 participants were recruited consisting of equal numbers of SCA and HbAA controls. Single lipid profiles were done; logarithms of triglycerides/high density lipoprotein were calculated to obtain AIP and lipid profile ratios established for all participants.

Results: there were lower mean values of Total Cholesterol (TC), High Density Lipoprotein(HDL) and Low Density Lipoprotein (LDL) amongst SCD participants than controls and higher mean values of triglycerides (TG) and Very Low Density Lipoprotein (VLDL) in SCD p < 0.05. The AIP in SCD ranges from -0.62 to 1.32 while that of controls ranges from -0.56 to 0.61.The mean AIP were 0.14 ± 0.29 and -0.009 ± 0.26 in SCD and controls respectively. P value = 0.002.

Conclusion: AIP value is higher in sickle cell anaemia than controls, the former have lower mean values of TC, HDL and LDL and higher mean values of TG and VLDL.

Published
2019-03-25
Section
Articles

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eISSN: 1937-8688