The prognostic value of serum uric acid in the acute phase of hemorrhagic stroke patients in black Africans

  • Yacouba Njankouo Mapoure Department of Clinical Sciences, University of Douala, Douala, Cameroon; Department of Internal Medicine, Douala General Hospital, Douala, Cameroon
  • Chia Mark Ayeah Department of Internal Medicine, Douala General Hospital, Douala, Cameroon; Department of Internal Medicine, Mboppi Baptist Hospital, Douala, Cameroon
  • Hamadou Ba Department of Internal Medicine, University of Yaoundé I, Douala, Cameroon
  • Hugo Bertrand Mbatchou Ngahane Department of Clinical Sciences, University of Douala, Douala, Cameroon; Department of Internal Medicine, Douala General Hospital, Douala, Cameroon
  • Romuald Hentchoya Service of Intensive Care Unit, Douala General Hospital, Douala, Cameroon
  • Henry Namme Luma Department of Internal Medicine, Douala General Hospital, Douala, Cameroon; Department of Internal Medicine, Mboppi Baptist Hospital, Douala, Cameroon
Keywords: Hyperuricemia; acute hemorrhagic stroke; mortality; functional outcome

Abstract

Introduction: very few studies have been conducted to evaluate the prevalence of hyperuricemia and its impact on the prognosis amongst acute hemorrhagic stroke (AHS) patients. The objectives was to determine the prevalence of hyperuricemia in AHS patients and examined the association between hyperuricemia and stroke outcomes in the Douala General Hospital (DGH).

Methods: this was a hospital based prospective cohort which included AHS patients with baseline SUA levels and 3 months post stroke follow-up data. SUA values were divided into quintiles. Associations between hyperuricemia and stroke outcomes were analyzed using multiple logistic regression and survival analysis (cox regression and Kaplan Meier).

 

Results: a total of 221 AHS patients were reviewed with a mean age of 55.8±11.8 years. The prevalence of hyperuricemia among AHS patients was 34.4% with mean SUA level of 376.8±131.9 µmol/l. On multivariate analysis, hyperuricemia was not independently associated with early death [(OR = 1.072 (CI: 0.370-3.056; p = 0.897)] and poor functional outcome [(OR=2.487 (CI: 0.771-8.699; p = 0.154)] after hemorrhagic stroke. No significant increase in stroke deaths was observed across higher SUA quintiles amongst hemorrhagic stroke patients (p = 0.326). No statistically significant correlation was observed between SUA level and NIHSS (r = 0.063, p = 0.353) and between SUA level and mRS (r = 0.030, p = 0.662) in hemorrhagic stroke.

Conclusion: about one third of patients present with hyperuricemia in the acute phase of hemorrhagic stroke. Hyperuricemia can act as risk factor for stroke because of its relationship with CVRFs but hyperuricemia has no impact on the severity and short-term outcome amongst black African hemorrhagic stroke patients.

Published
2019-04-09
Section
Articles

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eISSN: 1937-8688