The influence of hyperbaric oxygenation therapy on recurrent myocardial infarction and two-year survival rate in acute myocardial infaction patients

  • EA Dotsenko
  • D Salivonchyk
  • N Nikulina
  • MO Welcome

Abstract

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Background: Surgical methods of acute myocardial infarction (MI) treatment possess a high clinical effectiveness, but there are limitations, related to the patient's state, medical resources and organizational problems. The development of new medical technologies allows for a better and effective non-surgical treatment and increases long-term prognosis.

Aim: To assess the influence of hyperbaric oxygenation (HBO) therapy on mortality rate and recurrent myocardial infarction (rMI) within a two-year monitoring.

Methods: The study involved 129 patients who suffered from acute MI, having undergone the standard therapy. The patients were divided at random into 2 groups: Group 1 (reference group, n=65); Group 2 (test group, n=64). Group 2 patients were given the traditional treatment, accompanied with (HBO) standard therapy by BLKS-307 (Russia, Moscow) single-seat apparatus (isopression for 40 minutes at a working pressure of 0.03 MPa). HBO therapy was applied on the 4th- 10th day following MI. The treatment course included 6 cycles, once per day. The clinical assessment was focused on clinical outcome: repeated MI and cardiovascular related mortality. Monitoring duration was two years.

Results: The study involved 129 MI patients. No complications were encountered with HBO therapy on post-MI patients. Use of HBO reduced rMI and increased survival especially in the first half year after MI.

Conclusion: HBO application that accompanied the acute MI traditional pharmacotherapy proved to reduce rMI within 2 years following inpatient discharge (the rate of rMI was 19% in the reference group and 5.3% in the test group, χ2=5.0, р<0.05). The joint application of HBO and modern drug regimen in treating acute MI makes it possible to raise the 2-year survival rate from 86.2% up to 94.7%.

 

Key words: Hyperbaric oxygenation, Myocardial infarction, Mortality rate

Published
2009-08-24
Section
Articles

Journal Identifiers


eISSN: 0795-3038