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Research Journal of Health Sciences

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Garcinia cambogia ethanolic extract protects the liver from ciprofloxacin-induced hepatoxicity

V.O. Ukwenya

Abstract


Objective: This study investigated the effects of the ethanolic extract of Garcinia cambogia on ciprofloxacin – induced hepatotoxicity.

Method: Twenty (20) adult male Wistar rats were divided into four groups; Group A were given ciprofloxacin only (150 mg/kg b.w), Group B were given ciprofloxacin (150 mg/kg b.w) and extract (400 mg/kg b.w) simultaneously, Group C were given extract only (400 mg/kg b.w) and Group D served as control and received 1.5ml of distilled water as placebo. Serum and liver tissue were collected and processed for biochemical and histological studies respectively.

Results: The result of this work showed significantly elevated levels of aspartate transaminase (ASP), alkaline phosphatase (ALP) and alanine transaminase (ALT) in ciprofloxacin-treated rats compared to the Garcinia cambogia-treated and control groups. The histological analysis also showed distortion of the lobular architecture and presence of inflammatory cells within the sinusoids and hepatocellular apoptosis in Group A.

Conclusion: The results showed that Garcinia cambogia attenuates the toxic effects of ciprofloxacine on the liver.

Keywords: hepatoxicity, lobular architecture, Garcinia cambogia, serum, enzyme markers




http://dx.doi.org/10.4314/rejhs.v7i2.8
AJOL African Journals Online