Solving an optimal control problem of hepatitis B virus dynamics: Efficacy of fuzzy logic strategy

Abstract

This work aims at using fuzzy logic strategy to solve a hepatitis B virus (HBV) optimal control problem. To test the efficacy of this numerical method, we compare numerical results with those obtained using direct method. We consider a patient under treatment during 12 months where the two drugs are taken as controls. The results are rather satisfactory. In particular, the reaction of HBV to drugs can be modeled and a feedback can be approximated by the solution of a linear quadratic problem. The drugs reduce the risk of HBV. Furthermore, results of both numerical methods are in good agreement with experimental data and this justifies the efficacy of fuzzy logic strategy in solving optimal control problems.