Evaluation of liver marker enzymes in diabetic subjects in the University of Port Harcourt Teaching Hospital (UPTH

Abstract

The activity levels of the liver marker enzymes; Aspartate and Alanine amino  transferases (AST and ALT), Alkaline Phosphatase (ALP) and Gamma glutamyltransferase (GGT) in diabetic and non-diabetic subjects within the ages of 25 to 86 were assayed. This study was for two weeks. The results indicated that the  plasma levels of AST and ALT from diabetic subjects increased significantly (p < 0.05 and p < 0.001) during the period of study while the plasma levels of ALP and GGT from the same subjects remained mostly constant and normal significantly (p < 0.05 and p < 0.001) during the period for the study. The findings in this study suggest that Diabetes mellitus does cause elevation of liver enzymes in humans.

Key words: Liver marker enzymes, enzymes activity levels, Diabetes Mellitus