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Effect of aqueous extract of <i>Gangronema latifolium</i> <i>(G. latifolium) (Utazi)</i> on n-acetyl-para-aminophenol (acetaminophen) - induced hepatic injury on Wistar albino rats


Godwin Delight Chigamezu
Wilfred Obaalologhi
Okure Victoria

Abstract

The present study investigated the effect of leaf extract of Gangronema latifolium (G. latifolium) on acetaminophen (APAP) - induced liver injury in Wistar albino rats. In this study, sixty (60) male Wistar albino rats were divided into five (5) groups of twelve (12) rats each. Animals in group 1 served as control group and received a placebo of 0.9% saline solution. Group 2 served as APAP control group, administered with 800 mg/kg body weight of APAP only. Groups 3, 4 and 5 served as the experimental groups and received oral dosage of 800 mg/kg body weight of APAP plus 150 mg/kg, 200 mg/kg and 250 mg/kg body weight of G. latifolium respectively. The results showed that the enzymatic activities of alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyl transferase (GGT) in the serum were decreased significantly (p ≤ 0.05) in the experimental groups dosed with 150 mg/kg, 200mg/kg and 250 mg/kg of G. latifolium respectively. For 150 mg/kg G. latifolium treated group, ALT decreased from 23.3 ± 7.31 to 9.00 ± 1.52 IU/L, while AST and ALP decreased from 17.6 ± 2.66 to 15.00 ± 1.00 IU/L and 92.8 ± 2.34 to 83.8 ± 7.94 IU/L respectively. In conclusion, the results showed that aqueous extract of G. latifolium has a protective effect on rat liver induced with APAP injury.


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eISSN: 1118-1931
print ISSN: 1118-1931