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South African Family Practice

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Cardiovascular effects and the use of nonsteroidal anti-inflammatory drugs

N Schellack

Abstract


Nonsteroidal anti-inflammatory drugs (NSAIDs) include the nonselective and the cyclo-oxygenase-2-specific inhibitors. These agents are used for pain associated with musculoskeletal conditions. The nonselective   anti-inflammatory drugs are still widely used, and are also freely available as over-the-counter analgesics. However, they carry the risk of serious  cardiovascular adverse effects, especially in patients who have a high,  pre-existing cardiovascular risk profile. It is imperative that physicians are aware of these risk factors and choose agents that have the best benefit-to-risk profile, while taking into consideration the patient’s individual risk profile.



http://dx.doi.org/10.1080/20786204.2014.10844578
AJOL African Journals Online