South African Family Practice

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Audit of failure rate of CoartemTM to treat falciparum malaria at single fourteen-day follow-up

CH Vaughan Williams, C La Cook, GFJ Henry, AJ Ross


Objective. To assess the failure rate of the new first line treatment regime for uncomplicated falciparum malaria in KwaZulu-Natal of CoartemTM tablets (20mg artemether and 120mg lumefantrine Novartis South Africa (PTY) Ltd). Design. A before-after study1. Setting. Ndumo Clinic, Ingwavuma District, KwaZulu-Natal, South Africa, February 2001. Study Group. 67 patients presenting to Ndumo clinic with uncomplicated malaria. diagnosed by symptoms and positive immunochromographic test for plasmodium falciparum. Main outcome measures. Trophozoite count on thick film at day 14. Results. All of the 58 follow-up slides obtained were negative. 8 patients failed to return, and 1 slide washed off. Only 43 smears were positive at day 0 of which 36 had follow-up smears. Conclusions. No resistance to CoartemTM was shown at day 14, and CoartemTM has been shown to be more effective at clearing falciparum malaria parasites than a previous regime of sulfadoxine/pyrimethamine with chloroquine.

Keywords: Falciparum malaria, artemether,Lumefantrine

SA Fam Prac Vol.25(3) 2002: 8-12

AJOL African Journals Online