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Evidence for zolpidem efficacy in brain damage


RP Clauss
HW Nel

Abstract

Previous reports have shown that zolpidem could reverse semi-coma and improve cerebral perfusion after brain injury. Studies in animals have implicated omega 1 GABAergic action as reason for this improvement. Evidence for the efficacy of zolpidem in a wide range of brain pathology is reviewed here and the mechanism of zolpidem in brain injury is considered from the perspective of diaschisis and neurological dormancy after brain injury.


Keywords: Zolpidem, brain injury, dormancy, diaschisis


South African Family Practice Vol. 47(3) 2005: 49-50

Journal Identifiers


eISSN: 2078-6204
print ISSN: 2078-6190