Evidence for zolpidem efficacy in brain damage

  • RP Clauss Department, Royal Surrey County Hospital, Guildford, Surrey, GU2 7XX, United Kingdom
  • HW Nel 9 Media Road, Pollack Park, Springs, South Africa
Keywords: zolpidem, brain injury, dormancy, diaschisis


Previous reports have shown that zolpidem could reverse semi-coma and improve cerebral perfusion after brain injury. Studies in animals have implicated omega 1 GABAergic action as reason for this improvement. Evidence for the efficacy of zolpidem in a wide range of brain pathology is reviewed here and the mechanism of zolpidem in brain injury is considered from the perspective of diaschisis and neurological dormancy after brain injury.

Keywords: Zolpidem, brain injury, dormancy, diaschisis

South African Family Practice Vol. 47(3) 2005: 49-50

Journal Identifiers

eISSN: 2078-6204
print ISSN: 2078-6190