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Synthesis and Biological Evaluation of Novel Thiosemicarbazone–Triazole Hybrid Compounds Antimalarial Agents
Abstract
Anovel series of thiosemicarbazone-triazole hybrids were efficiently synthesized and evaluated for their activity against the 3D7 strain of the malaria parasite, Plasmodium falciparum. Although the hybrids were found not to be as potent as the standard chloroquine, they have shown activities interesting enough to warrant future structure activity relationship (SAR) studies.
KEY WORDS Thiosemicarbazone, triazole, hybrid, antimalarial.
