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Published:
Oct 8, 2015Keywords:
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Synthesis and Antimicrobial Activity of 2-(Aminoacid ester)-3-(6-methyl-2-pyridyl)-3,4-dihydro-2<i>H</i>-1,3,2 λ<sup>5</sup>- benzoxazaphosphinin-2-thiones
Abstract
Synthesis of 2-(aminoacid ester)-3-(6-methyl-2-pyridyl)-3,4-dihydro-2H-1,3,2λ5-benzoxazaphosphinin-2-thiones (3a–j) was accomplished through a two-step process. It involves the prior preparation of 2-chloro-3-(6-methyl-2-pyridyl)-3,4-dihydro-2H-1,3,2λ5-benzoxazaphosphinin-2-thione monochloride (2) and its subsequent reaction with the aminoacid ester hydrochlorides in dry tetrahydrofuran-toluene in the presence of triethylamine at various temperatures. These compounds were characterized
by IR, 1H, 13C, 31P NMR and mass spectral data.
Keywords: 2-[(6-methyl-2-pyridyl) amino] methylphenol, 1,3,2-benzoxazaphosphinin-2-thione, antimicrobial activity
