Article Sidebar
Published:
Oct 13, 2015Keywords:
Article Details
Copyright for articles published in this journal is retained by the journal.
SAJChem applies the Creative Commons Attribution (CC BY) license to manuscripts we publish. This license was developed to facilitate open access – namely, free immediate access to, and unrestricted reuse of, original works of all types. Under this license, authors agree to make articles legally available for reuse, without permission or fees, for virtually any purpose. Anyone may copy, distribute or reuse these articles, as long as the author and original source are properly cited.
Main Article Content
Expedient Access to an <i>N</I>-phenylpyrrolidin-2-yl Heterocycle <i>via</i> a Base-Induced Intramolecular <i>aza</i>-Michael Reaction
Abstract
Ethyl 2-(1-phenylpiperidin-2-yl) acetate was formed in a spontaneous cyclization from (E)-ethyl 7-oxohept-2-enoate whereas ethyl [1-(2-bromophenyl)-2-pyrrolidinyl] acetate could be synthesized in good overall yield when employing a stoichiometric amount of base to facilitate the intramolecular aza-Michael reaction.
Keywords: aza Michael, intramolecular, catalysed, piperidine, pyrrolidine, base
