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Oct 14, 2015Keywords:
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An Environmentally Friendly Solvent-free Synthesis of 3,4-Dihydropyrimidinones using a <i>p</i>-Aminobenzene Sulfonic Acid Catalyzed Biginelli Reaction
Abstract
Anhydrous p-aminobenzene sulphonic acid mediated solvent-free protocol is described for the synthesis of dihydropyrimidinones by the cyclocondensation of aldehydes, β-ketoesters and urea/thiourea. Yields obtained are significantly higher than those obtained utilizing classical Biginelli reaction conditions.
Keywords: Anhydrous p-aminobenzene Sulphonic Acid, 3,4-dihydropyrimidinones, Biginelli Reaction
