A Simple and Efficient Synthesis of 12-Aryl-8,9,10,12- tetrahydrobenzo[a]xanthen-11-ones by ZnO Nanoparticles Catalyzed Three Component Coupling Reaction of Aldehydes, 2-Naphthol and Dimedone

  • J Safaei-Ghomi
  • MA Ghasemzadeh
Keywords: ZnO, nanoparticles, tetrahydrobenzo[a]xanthen-11-one, multi-component reactions, heterocyclic compounds.


Highly effective zinc oxide nanoparticles catalyzed solvent-free synthesis of some tetrahydrobenzo[a]xanthen-11-one derivatives via one-pot multi-component reaction of aldehydes, 2-naphthol and dimedone. The present approach creates a variety of biologically active heterocyclic compounds in excellent yields and short reaction times. Four new compounds are reported. The salient features of the ZnO nanoparticles are: easy preparation, cost-effective, high stability, low loading and reusability of the catalyst. The prepared zinc oxide nanoparticles were fully characterized by EDX, XRD, SEM, IR and TEM analysis.

KEYWORDS: ZnO, nanoparticles, tetrahydrobenzo[a]xanthen-11-one, multi-component reactions,  heterocyclic compounds.


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eISSN: 0379-4350