Synthesis of Novel Piperazine-linked Anthranilic Acids as Potential Small Molecule Kinase Inhibitors

  • S Chakravorty
  • HF Kleina
  • LE Hodson
  • M Rabillier
  • Z Fang
  • A Richters
  • SC Pelly
  • D Rauh
  • WAL van Otterlo
Keywords: Small molecule kinase inhibitors, anthranilic acid, piperazines, EGFR.

Abstract

Substituted anthranilic acid and piperazines were used as building blocks to prepare two libraries of  compounds, with the aim being that they would exhibit biochemical activity as small molecule kinase inhibitors. The synthesized anthranilamidepiperazine compounds were subsequently tested against a panel of kinases including EGFR, Abl, Akt and Aurora B.


KEYWORDS: Small molecule kinase inhibitors, anthranilic acid, piperazines, EGFR.

Published
2015-09-18
Section
Articles

Journal Identifiers


eISSN: 0379-4350