Characterization and Cardiovascular Effects of (13S)-9α,13α-epoxylabda-6β(19),15(14)diol Dilactone, a Diterpenoid Isolated from Leonotis leonurus
A new diterpenoid, (13S)-9α,13α-epoxylabda-6(19),15(14)diol dilactone (1), was isolated from Leonotis leonurus and the structure determined via NMR analysis. The compound causes significant changes in blood pressure of anaesthetized normotensive rats and exhibits a negative chronotropic effect.
Keywords: Leonotis leonurus, diterpenoid, NMR analysis, chronotropic effect
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