Synthesis and Biological Evaluation of some Anthranilic Acid and 2-Phenylquinazoline-4(3H)-one Analogues
In the present investigation a novel series of N-(phenyl) chalconyl anthranilic acids containing pyrazolines (4a–j), tetrahydropyrimidines (4k–o), tetrahydrothiopyrimidines (4p–t) and 2-phenylquinazolin-4(3H)-ones containing pyrazolines (8a–f), isoxazolines (8g–l), tetrahydropyrimidines (8m–r) and tetrahydrothiopyrimidines (8s–x) were synthesized and characterized by elemental analysis, FT-IR, 1H NMR and mass spectroscopy. The title compounds (4a–t) and (8a–x) were investigated for their analgesic, anti-inflammatory, antimicrobial and in vitro protein denaturation activities. Compounds 4j and 8x were identified as lead compounds with optimum analgesic, anti-inflammatory and antimicrobial activities.
Keywords: Quinazolines, antimicrobial, analgesic, anti-inflammatory, protein denaturation
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