Rapid Synthesis of 2-Substituted-2,3-dihydro-4(1H)-quinazolinones using Boric Acid or Sodium Dihydrogen Phosphate under Solvent-Free Conditions

  • Z Karimi-Jaberi
  • L Zarei
Keywords: Dihydroquinazolinones, boric acid, sodium dihydrogen phosphate, 2-anthranilamide, solvent-free synthesis

Abstract

Two efficient and convenient methods have been described for synthesis of 2-substituted-2,3-dihydro-4(1H)-quinazolinone derivatives by one-pot condensation of 2-anthranilamide with aldehydes or ketones in the presence of a catalytic amount of boric acid or sodium dihydrogen phosphate under solvent-free conditions. The attractive features of these processes are short reaction times, easy isolation of products, excellent yields and an environmental friendly procedure.

Keywords: Dihydroquinazolinones, boric acid, sodium dihydrogen phosphate, 2-anthranilamide, solvent-free synthesis

Published
2015-10-13
Section
Articles

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eISSN: 0379-4350