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Published:
Oct 14, 2015Keywords:
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Euphorbias of South Africa: Two New Phorbol Esters from <i>Euphorbia bothae</i>
Abstract
Two known phorbol esters, 12-deoxyphorbol-13-isobutyrate-20-acetate (1) and 12-deoxyphorbol-13-(2-methylbutyrate)-20-acetate (2), and two new phorbol esters, 12-deoxyphorbol-13-isobutyrate-16-angelate-20-acetate (3) and 12-deoxyphorbol-13-(2-methylbutyrate)-16-angelate-20-acetate (4), were isolated from the endemic SouthAfrican plant Euphorbia bothae. Standard spectroscopic techniques were used to elucidate the structures of all four compounds. The interaction of 1–4 with opioid receptors was explored in an attempt to explain the unexplained stupor occasionally observed in herbivores browsing on E. bothae.
Keywords: Euphorbia bothae, Euphorbiaceae, Phorbol Ester, Opioid Receptor
