Can measuring immunity to HIV during antiretroviral therapy (ART) in children provide a clue to markers of ART effectiveness?
The vexing issue of whether the immune system can be reconstituted during HIV infection by supplying antiretroviral therapy (ART) has been a question asked about HIV-infected adults and children receiving therapy.1-9 Knowing that the immune system
is sufficiently plastic in adults to show restoration of specific and general immunity after receiving ART is promising when translated to paediatric treatment. There is evidence in children of immune reconstitution after receiving various therapeutic regimens.2,10 This review will examine some of the aspects of immune restoration in general, and specifically in children, and pose the question whether knowledge of changes in immunity in tandem with viral suppression can provide clues as to how to measure immune efficacy of ART.
Southern African Journal of HIV Medicine Vol. 6 (4) 2005: pp. 42-45