A patient with multiple iris
TThe immune reconstitution inflammatory syndrome (IRIS) is a frequent early complication of antiretroviral therapy (ART), particularly in patients who commence ART with low CD4 counts and established opportunistic infections. IRIS results from a pathological inflammatory response to pre-existing infective, host or other antigens, alive or dead, causing clinical deterioration in HIV-infected patients after initiating ART.1 A case definition for IRIS is shown in Table I. The most common forms of IRIS described occur in association with mycobacterial and herpesvirus infections.3 We describe here a patient who presented with IRIS in association with tuberculosis (TB), then cryptococcosis, and later varicella zoster virus (VZV).
Southern African Journal of HIV Medicine Vol. 8 (3) 2007: pp. 57-60