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South African Journal of Surgery

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Ten-year survival of patients with oesophageal squamous cell carcinoma

W Hu, Y Liang, S Zhang, Y Hu, J Liu

Abstract


Objectives. The standard predictive factors of actuarial survival such as T and N stage become less important as patients live for more than 10
years after treatment of cancer. Reports of actual 10-year survivors of oesophageal squamous cell carcinoma (SCC) are rare, and demographic
and clinicopathological factors associated with 10-year survival have not been well documented. In this research we evaluated factors predictive
of actual, as opposed to actuarial, 10-year survival.
Methods. We retrospectively analysed 1 046 patients who had undergone oesophagectomy for oesophageal SCC. The demographic and clinicopathological characteristics of patients who were alive more than 10 years after oesophagectomy and those of patients who had died
were compared.
Results. Univariate analysis showed that 18 factors differed significantly between the two groups. Based on logistic regression analysis, factors associated with 10-year survival were younger age, female gender, absence of dysphagia, a left transthoracic surgical approach, lower
pathological T stage, and fewer metastatic lymph nodes.
Conclusion. The independent positive predictors of actual as opposed to actuarial 10-year survival are younger age, female gender, absence of
dysphagia, lower pathological T stage, and fewer metastatic lymph nodes.



http://dx.doi.org/10.7196/sajs.1453
AJOL African Journals Online