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Multiple Myeloma


G Shulman
K Stevens
DB Bernard
TH Bothwell
WR Bezwoda
SR Lynch

Abstract

The clinical, biochemical and immunochemical features of 52 patients suffering from multiple myelomatosis are reported. Three major criteria were used to establish the diagnosis: serum and urine protein chemistry, bone marrow morphology and the radiological appearances of bone. The fact that abnormalities of gamma globulin synthesis were present in 49 of the 52 patients indicates the importance of adequate examination of urine by electrophores's and immunochemical techniques in the early diagnosis of multiple myeloma. Bradshaw's test, which is a simple screening test for fence-Jones proteinuria, was positive in 63% of patients.

S. Afr. Med. J., 48, 1023 (1974).

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eISSN: 2078-5135
print ISSN: 0256-9574