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Pathology of Gaucher's Disease


LB Kahn

Abstract

A review of the pathology of t 2 cases of non-neuronopathic type Gaucher's disease, diagnosed over a 38-year period, t 935 to 1973, is presented. One of these patients is described in detail and an unusual association with a splenic epidermoid cyst in an unaffected sibling is documented. Histochemical studies have confirmed the presence of an abundance of acid phosphatase in the cytoplasm of the Gaucher cells, while ultrastructural examination has confirmed the presence of single membrane-bound sacs containing tubular structures with a right-handed helical twist.

S. Afr. Med. J., 48, 1098 (1974)

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eISSN: 2078-5135
print ISSN: 0256-9574