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Pressurised aerosols


MH Durr

Abstract

Data available on the increase in sudden asthma deaths during 1964 to 1967 in a number of countries do not allow for the condemnation of pressurised aerosols. It appears that highly ,8rselective pressurised aerosols (fenoterol and salbutamol) do not have cardiovascular actions. Doses 12 times those required for bronchodilation do not affect heart rate. It is assumed that selective-,8, adrenoceptor stimulants have a topical action on receptors in the mouth and pharynx. As this assumption does not explain the immediate action on bronchospasm and on uterine motility in preterm labour, the existence of a still unknown and hypothetical reflex mechanism cannot be excluded. The topical actions and the minute doses absorbed render the inhalation of selective ,82-adrenoceptor stimulants very safe treatment.

S. Afr. Med. J 48, 1959 (1974).

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eISSN: 2078-5135
print ISSN: 0256-9574