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The effect of Symmetrel (Amantadine hydrochloride) on a case of Athetosis
Abstract
The results of a double-blind cross-over trial comparing Symmetrel against placebo in a child suffering from severe athetosis are presented. No major benefit is claimed as a result of the administration of Symmetrel. Nevertheless, there was objective evidence of a beneficial drug effect. There was a measurable diminution in the number of athetoid eye movements and upper lip movements when the patient was on Symmetrel compared with the periods when she was off the drug. The incidence of cyanotic attacks and degree of salivation also appeared to improve. The fact that the drug appears to have had some demonstrable effect on the athetoid movements indicates a need for further clinical studies. In addition, it would appear worth while to investigate chemical analogues and derivatives of Symmetrel in the hope that more sophisticated compounds can be developed for the treatment of athetosis and allied disorders.
