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Aspects of experimental hepatocarcinogenesis<br>Part V. ultrastructural morphology of early hepatocellular carcinomas


A.H. Timme

Abstract

A study has been made of 6 hepatocellular nodules which arose in the cirrhotic livers of rats fed p-dimethylaminoazobenzene (p-DAB). Four of the nodules which were composed of well-differentiated liver cells were non-invasive, but 2, although Indistinguishable from the 4 in other respects, showed limited signs of infiltiation of adjacent parenchyma. With tho electron microscope, the liver cells comprising the nodules were found to be fairly well differentiated and contained normal microbodies, desmosomes and bile canaliculi. It was concluded that the 6 nodules represented early, well-differentiated carcinomas, although 4 were in a non-invasive stage.

S. Afr. Med. J., 48, -1335 (1974).

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eISSN: 2078-5135
print ISSN: 0256-9574