Problems in the optimal management of myasthenia gravis patients - A prospective clinical survey at Kalafong hospital

  • NA Mafojane
  • PLA Bill
  • BP Lotz


Objectives. This study forms part of a clinical survey of problems in the optimal management of patients  with inherited  neuromuscular diseases seen at Kalafong Hospital in Pretoria. Our objectives  were to determine the problems associated with providing patients with optimal management until true remission (cure), and to apply the findings to ongoing improvement of optimal management. This is the first report of the series.

Methods. Twenty-six patients were studied prospectively from 1986to1998. Early sternal-splitting  thymectomy on class II -V patients as well as anticholinesterases, corticosteroids, azathioprine, plasma exchange, intensive care and various combinations of these constituted part of the optimal management. An assessment of the total monthly income and distance from hospital was done for each patient.

Results. Five of the 15 thymectomised patients (33.3%) were lost to follow-up after reaching remission.  Of the remaining 10 patients, 6 (40%) are in true remission and the remaining 4 (26.7%) are in  pharmacological remission. Four of the 11 patients (36%) treated non-surgically were lost to follow-up. Of the remaining patients, 1 (9.1 % ) is in true remission and the remaining 6 (54.5%) are in   pharmacological remission. The average monthly income of patients lost to follow-up in the   thymectomised group was lower than that of patients who continued follow-up, and their homes were   further away from hospital. In the non-surgical group the average monthly income of patients lost to  follow-up was higher than that of patients who continued follow-up and their homes were nearer to the  hospital.

Conclusion. Early thymectomy (the aggressive approach) resulted in 40% cures, 26.7%  pharmacological remissions, no mortality, minimal morbidity, and early discharge. Loss to follow-up was one of the biggest problems in providing optimal management for these patients.We modified optimal management in response to our patients' concerns without sacrificing excellence, and found that poverty and poor access to tertiary hospitals were possible contributory factors to loss to follow-up. Suggestions are made with regard to tackling the problems. Myasthenia gravis (MG) is a disorder of neuromuscular function resulting from an immunologically based premature destruction of acetylcholine receptors.


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eISSN: 0256-95749
print ISSN: 2078-5135