Adult influenza vaccination guideline
Objective. To outline a rational cost-effective protocol for influenza vaccination of adults in South Africa.
Vaccine description. An inactivated (killed) virus vaccine containing three virus strains representing those most likely to circulate in the southern hemisphere during the upcoming winter. Vaccine success depends on the patient's age, immune system status, and degree of similarity of the virus strains contained in the vaccine to those circulating in the community.
Recommendations. Vaccination is: • potentially beneficial to any individual • very effective in young otherwise healthy individuals • targeted at high-risk groups when there is limited availability and cost considerations.
Evidence. Detailed literature review with emphasis on local South African studies.
Benefits, harms, costs. Successful vaccination may be effective. in protecting against acute respiratory tract infection, and preventing hospitalisation, complicating pneumonia and death. The vaccine is safe with only occasional reports of anaphylaxis. Contraindications to the vaccine are anaphylactic hypersensitivity to eggs, allergy to other components of the vaccine, and acute severe febrile illness. Vaccine cost-effectiveness has been confirmed in several groups, including healthy working adults, elderly living in the community, elderly with underlying chronic medical disorders.
Validation. Endorsement by the SA Pulmonology Society, SAMA and all who attended a multidisciplinary consensus meeting to consider the draft guideline.
Financial sponsor. Development supported by an umestricted educational grant by Pasteur Merieux Connaught to SAMA
Copyright remains in the Author’s name. The work is licensed under a Creative Commons Attribution - Noncommercial Works License. Authors are required to complete and sign an Author Agreement form that outlines Author and Publisher rights and terms of publication. The Agreement form should be uploaded along with other submissions files and any submission will be considered incomplete without it [forthcoming].
Material submitted for publication in the SAMJ is accepted provided it has not been published or submitted for publication elsewhere. Please inform the editorial team if the main findings of your paper have been presented at a conference and published in abstract form, to avoid copyright infringement. The SAMJ does not hold itself responsible for statements made by the authors.
Previously published images
If an image/figure has been previously published, permission to reproduce or alter it must be obtained by the authors from the original publisher and the figure legend must give full credit to the original source. This credit should be accompanied by a letter indicating that permission to reproduce the image has been granted to the author/s. This letter should be uploaded as a supplementary file during submission.