Evaluation of reflux oesophagitis with technetium-99m-labelled sucralfate

  • JH van Zyl
  • MG Nel
  • AC Otto
  • H de K. Grundling
  • E. Reinecke
  • JM Botha

Abstract

Sucralfate binds with denuded protein to form a stable complex to protect the damaged mucosa. By utilising this property, technetium-99m-labelled sucraJfate can be used to demonstrate ulceration in the upper gastro-intestinal tract. Aim: The aim of this study was to evaluate 99mTc-labelled sucralfate in the diagnosis of grade 11 - III reflux oesophagitis. Methods: Ten patients with endoscopic proof of grade 11 - III reflux oesophagitis and 10 patients wrth normal findings on oesophagoscopy were evaluated after they had swallowed 5 rnl 99mTc sucralfate. Radionuclide imaging was done until activity in the oesophagus had ceased. Results: Retention of activity from 10 minutes up to 11/2 hours could be demonstrated in 9 patients with endoscopically proven oesophagitis. In the control group complete clearance of activity was seen in 7 patients. Gastro-oesophageal reflux could be demonstrated in 4 patients. Conclusion: 99mTc sucralfate is a sensrtive and specific method for the non-invasive diagnosis of oesophagitis compared with endoscopy.

S Afr Med J 1996; 66: 1422-1424

Author Biographies

JH van Zyl
Departments of Internal Medicine (Division: Gastroenterology), Nuclear Medicine and Biophysics, University of the Orange Free State, Bloemfontein
MG Nel
Departments of Internal Medicine (Division: Gastroenterology), Nuclear Medicine and Biophysics, University of the Orange Free State, Bloemfontein
AC Otto
Departments of Internal Medicine (Division: Gastroenterology), Nuclear Medicine and Biophysics, University of the Orange Free State, Bloemfontein
H de K. Grundling
Departments of Internal Medicine (Division: Gastroenterology), Nuclear Medicine and Biophysics, University of the Orange Free State, Bloemfontein
E. Reinecke
Departments of Internal Medicine (Division: Gastroenterology), Nuclear Medicine and Biophysics, University of the Orange Free State, Bloemfontein
JM Botha
Departments of Internal Medicine (Division: Gastroenterology), Nuclear Medicine and Biophysics, University of the Orange Free State, Bloemfontein
Published
2017-06-08
Section
Articles

Journal Identifiers


eISSN: 0256-95749
print ISSN: 2078-5135