Evaluation of reflux oesophagitis with technetium-99m-labelled sucralfate
AbstractSucralfate binds with denuded protein to form a stable complex to protect the damaged mucosa. By utilising this property, technetium-99m-labelled sucraJfate can be used to demonstrate ulceration in the upper gastro-intestinal tract. Aim: The aim of this study was to evaluate 99mTc-labelled sucralfate in the diagnosis of grade 11 - III reflux oesophagitis. Methods: Ten patients with endoscopic proof of grade 11 - III reflux oesophagitis and 10 patients wrth normal findings on oesophagoscopy were evaluated after they had swallowed 5 rnl 99mTc sucralfate. Radionuclide imaging was done until activity in the oesophagus had ceased. Results: Retention of activity from 10 minutes up to 11/2 hours could be demonstrated in 9 patients with endoscopically proven oesophagitis. In the control group complete clearance of activity was seen in 7 patients. Gastro-oesophageal reflux could be demonstrated in 4 patients. Conclusion: 99mTc sucralfate is a sensrtive and specific method for the non-invasive diagnosis of oesophagitis compared with endoscopy.
S Afr Med J 1996; 66: 1422-1424
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