In vitro activity of a new 'higher-lactam' antibacterial agent LY 193239

  • P.L. Botha
  • E Vorster
  • C. Jordaan

Abstract

In vitro activity ofthe new bicyclic pyrazolidinone LY 193239 (Eli Lilly) was evaluated against 52 clinical isolates of Haemophilus influenzae (4 were β-lactamase producers), 32 Enterococcus faecalis, 14 Neisseria gonorrhoeae (1 β-lactamasepositive) and 19 Neisseria meningitidis. Activity was best against Neisseria spp. and H. influenzae, including penicillinase- producing strains. Results of the time-kill study against a non-enzyme-mediated penicillin resistant strain of N. meningitidis indicate that exposure to an antibacterial concentration four times the minimal inhibitory concentration was bactericidal. E. faecalis was insensitive.

Section
Articles

Journal Identifiers


eISSN: 0256-95749
print ISSN: 2078-5135