Aspects of Experimental Hepatocarcinogenesis

  • AH Timme


This article, the first of a series of 5, describes the light and electron microscopical features of early foci of parenchymaI cell hyperplasia which developed in the livers of rats fed the carcinogen p-dimethylaminoazobenzene (butter yellow). The cells in the foci possessed increased numbers of free cytoplasmic ribosomes, prominent perinuclear Golgi bodies and bundles of microfilaments. These features suggested that the cells were not merely regenerative in nature but represented a definite carcinogen-induced proliferative response.

S. Afr. Med. J., 48, 698 (1974)

Author Biography

AH Timme
Department of Pathology, Groote Schuur Hospital and University of Cape Town

Journal Identifiers

eISSN: 0256-95749
print ISSN: 2078-5135