Prevention of folate deficiency by food fortification

  • N Colman
  • R Green
  • K Stevens
  • J Metz

Abstract

The antimegaloblastic effect of cooked folic acid-fortified maize meal was tested by feeding the meal to 5 lactating patients with folate-deficient megaloblastic anaemia. The dose of folic acid in the meal before cooking varied from 100 to 500 µg daily. One patient who received 100 µg daily had a suboptimal haematological response. Meal containing 300 µg and 500 µg daily produced optimal haematological response in all 4 patients so treated, and there was no secondary reticulocyte response in the 2 patients subsequently given pharmacological doses of folic acid. It is concluded that the fortified meal after cooking is an effective antimegaloblastic agent.

S. Afr. Med. J., 48, 1795 (1974).

Author Biographies

N Colman
Department of Haematology, School of Pathology, South African Institute for Medical Research, and University of the Witwatersrand, Johannesburg
R Green
Department of Haematology, School of Pathology, South African Institute for Medical Research, and University of the Witwatersrand, Johannesburg
K Stevens
Department of Haematology, School of Pathology, South African Institute for Medical Research, and University of the Witwatersrand, Johannesburg
J Metz
Department of Haematology, School of Pathology, South African Institute for Medical Research, and University of the Witwatersrand, Johannesburg
Published
2018-04-08
Section
Articles

Journal Identifiers


eISSN: 0256-95749
print ISSN: 2078-5135