Prevention of folate deficiency by food fortification
AbstractThe antimegaloblastic effect of cooked folic acid-fortified maize meal was tested by feeding the meal to 5 lactating patients with folate-deficient megaloblastic anaemia. The dose of folic acid in the meal before cooking varied from 100 to 500 µg daily. One patient who received 100 µg daily had a suboptimal haematological response. Meal containing 300 µg and 500 µg daily produced optimal haematological response in all 4 patients so treated, and there was no secondary reticulocyte response in the 2 patients subsequently given pharmacological doses of folic acid. It is concluded that the fortified meal after cooking is an effective antimegaloblastic agent.
S. Afr. Med. J., 48, 1795 (1974).
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