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Oral metiamide as an effective inhibitor of gastric acid secretion in man


GO Barbezat
S Bank
J Clain
B Novis
IN Marks

Abstract

A method is described for the evaluation of the effect of oral therapy on gastric acid secretion. Metiamide, a histamine H2-receptor antagonist, produced a 51% inhibition of pentagastrin-stimulated gastric acid secretion during the third hour after a standard 200-mg oral dose in man.

S. Afr. Med. J., 48, 2018 (1974).

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eISSN: 2078-5135
print ISSN: 0256-9574