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South African Medical Journal

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Oral metiamide as an effective inhibitor of gastric acid secretion in man

GO Barbezat, S Bank, J Clain, B Novis, IN Marks

Abstract


A method is described for the evaluation of the effect of oral therapy on gastric acid secretion. Metiamide, a histamine H2-receptor antagonist, produced a 51% inhibition of pentagastrin-stimulated gastric acid secretion during the third hour after a standard 200-mg oral dose in man.

S. Afr. Med. J., 48, 2018 (1974).



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