South African Medical Journal

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Diprosone ointment in psoriasis

CM Ross


A double-blind trial which compared the effects of two topical steroids on 58 successive cases of psoriasis is reported. The investigations compared the efficacy and cosmetic acceptability of betamethasone dipropionate ointment (Diprosone) with that of fluclorolone acetonide ointment (Topilar). Under the conditions of the trial, the betamethasone dipropionate ointment in a concentration of 0,05% was significantly superior to 0,025% fluclorolone acetonide ointment in both the patient's over-all evaluation (P<0,024) and in the investigator's over-all evaluation (P<0,008); in the relief of pruritus noted by the patient (P<0,063) and in the degree of improvement in scaling observed by the investigator (P<0,080). The phenomenon of sweating in patches of psoriasis is discussed.

S. Afr. Med. J., 48, 2030 (1974).

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